Eosinophils and IL-33 perpetuate chronic inflammation and fibrosis in a pediatric population with stricturing Crohn’s ileitis

BACKGROUND: Fibrostenosis and stricture are well-recognized endpoints in Crohn’s disease (CD). We hypothesized that stricturing-CD is characterized by eosinophilia and epithelial-IL-33. We proposed that eosinophil exposure to IL-33 would perpetuate inflammatory chronicity and subsequent fibrostenosi...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Inflamm Bowel Dis
Huvudupphovsmän: Masterson, Joanne C., Capocelli, Kelley E., Hosford, Lindsay, Biette, Kathryn, McNamee, Eóin N., de Zoeten, Edwin F, Harris, Rachel, Fernando, Shahan D., Jedlicka, Paul, Protheroe, Cheryl, Lee, James J., Furuta, Glenn T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567482/
https://ncbi.nlm.nih.gov/pubmed/26218140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0000000000000512
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk