Eosinophils and IL-33 perpetuate chronic inflammation and fibrosis in a pediatric population with stricturing Crohn’s ileitis

BACKGROUND: Fibrostenosis and stricture are well-recognized endpoints in Crohn’s disease (CD). We hypothesized that stricturing-CD is characterized by eosinophilia and epithelial-IL-33. We proposed that eosinophil exposure to IL-33 would perpetuate inflammatory chronicity and subsequent fibrostenosi...

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Publicat a:Inflamm Bowel Dis
Autors principals: Masterson, Joanne C., Capocelli, Kelley E., Hosford, Lindsay, Biette, Kathryn, McNamee, Eóin N., de Zoeten, Edwin F, Harris, Rachel, Fernando, Shahan D., Jedlicka, Paul, Protheroe, Cheryl, Lee, James J., Furuta, Glenn T.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567482/
https://ncbi.nlm.nih.gov/pubmed/26218140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0000000000000512
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