Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis

OBJECTIVE: Eosinophilic oesophagitis (EoE) is a chronic inflammatory condition of the oesophagus with limited treatment options. No previous transgenic model has specifically targeted the oesophageal mucosa to induce oesophageal eosinophilia. DESIGN: We developed a mouse model that closely resembles...

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Detalhes bibliográficos
Main Authors: Masterson, Joanne C, McNamee, Eóin N, Hosford, Lindsay, Capocelli, Kelley E, Ruybal, Joseph, Fillon, Sophie A, Doyle, Alfred D, Eltzschig, Holger K, Rustgi, Anil K, Protheroe, Cheryl A, Lee, Nancy A, Lee, James J, Furuta, Glenn T
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3884674/
https://ncbi.nlm.nih.gov/pubmed/23161496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2012-303631
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