Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis

OBJECTIVE: Eosinophilic oesophagitis (EoE) is a chronic inflammatory condition of the oesophagus with limited treatment options. No previous transgenic model has specifically targeted the oesophageal mucosa to induce oesophageal eosinophilia. DESIGN: We developed a mouse model that closely resembles...

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Bibliografiset tiedot
Päätekijät: Masterson, Joanne C, McNamee, Eóin N, Hosford, Lindsay, Capocelli, Kelley E, Ruybal, Joseph, Fillon, Sophie A, Doyle, Alfred D, Eltzschig, Holger K, Rustgi, Anil K, Protheroe, Cheryl A, Lee, Nancy A, Lee, James J, Furuta, Glenn T
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3884674/
https://ncbi.nlm.nih.gov/pubmed/23161496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2012-303631
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