Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis

OBJECTIVE: Eosinophilic oesophagitis (EoE) is a chronic inflammatory condition of the oesophagus with limited treatment options. No previous transgenic model has specifically targeted the oesophageal mucosa to induce oesophageal eosinophilia. DESIGN: We developed a mouse model that closely resembles...

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Autores principales: Masterson, Joanne C, McNamee, Eóin N, Hosford, Lindsay, Capocelli, Kelley E, Ruybal, Joseph, Fillon, Sophie A, Doyle, Alfred D, Eltzschig, Holger K, Rustgi, Anil K, Protheroe, Cheryl A, Lee, Nancy A, Lee, James J, Furuta, Glenn T
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3884674/
https://ncbi.nlm.nih.gov/pubmed/23161496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2012-303631
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