Eosinophils and IL-33 perpetuate chronic inflammation and fibrosis in a pediatric population with stricturing Crohn’s ileitis

BACKGROUND: Fibrostenosis and stricture are well-recognized endpoints in Crohn’s disease (CD). We hypothesized that stricturing-CD is characterized by eosinophilia and epithelial-IL-33. We proposed that eosinophil exposure to IL-33 would perpetuate inflammatory chronicity and subsequent fibrostenosi...

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發表在:Inflamm Bowel Dis
Main Authors: Masterson, Joanne C., Capocelli, Kelley E., Hosford, Lindsay, Biette, Kathryn, McNamee, Eóin N., de Zoeten, Edwin F, Harris, Rachel, Fernando, Shahan D., Jedlicka, Paul, Protheroe, Cheryl, Lee, James J., Furuta, Glenn T.
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567482/
https://ncbi.nlm.nih.gov/pubmed/26218140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0000000000000512
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