Epithelial HIF-1α/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis

Epithelial barrier dysfunction is a significant factor in many allergic diseases, including eosinophilic esophagitis (EoE). Infiltrating leukocytes and tissue adaptations increase metabolic demands and decrease oxygen availability at barrier surfaces. Understanding of how these processes impact barr...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Masterson, Joanne C., Biette, Kathryn A., Hammer, Juliet A., Nguyen, Nathalie, Capocelli, Kelley E., Saeedi, Bejan J., Harris, Rachel F., Fernando, Shahan D., Hosford, Lindsay B., Kelly, Caleb J., Campbell, Eric L., Ehrentraut, Stefan F., Ahmed, Faria N., Nakagawa, Hiroshi, Lee, James J., McNamee, Eóin N., Glover, Louise E., Colgan, Sean P., Furuta, Glenn T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668670/
https://ncbi.nlm.nih.gov/pubmed/31264974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126744
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