Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis

Mucosal surfaces of the lower gastrointestinal tract are subject to frequent, pronounced fluctuations in oxygen tension, particularly during inflammation. Adaptive responses to hypoxia are orchestrated largely by the hypoxia-inducible transcription factors (HIFs). As HIF-1α and HIF-2α are coexpresse...

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Autori principali: Glover, Louise E., Bowers, Brittelle E., Saeedi, Bejan, Ehrentraut, Stefan F., Campbell, Eric L., Bayless, Amanda J., Dobrinskikh, Evgenia, Kendrick, Agnieszka A., Kelly, Caleb J., Burgess, Adrianne, Miller, Lauren, Kominsky, Douglas J., Jedlicka, Paul, Colgan, Sean P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856803/
https://ncbi.nlm.nih.gov/pubmed/24248342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302840110
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