Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis

Mucosal surfaces of the lower gastrointestinal tract are subject to frequent, pronounced fluctuations in oxygen tension, particularly during inflammation. Adaptive responses to hypoxia are orchestrated largely by the hypoxia-inducible transcription factors (HIFs). As HIF-1α and HIF-2α are coexpresse...

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Bibliografische gegevens
Hoofdauteurs: Glover, Louise E., Bowers, Brittelle E., Saeedi, Bejan, Ehrentraut, Stefan F., Campbell, Eric L., Bayless, Amanda J., Dobrinskikh, Evgenia, Kendrick, Agnieszka A., Kelly, Caleb J., Burgess, Adrianne, Miller, Lauren, Kominsky, Douglas J., Jedlicka, Paul, Colgan, Sean P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2013
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856803/
https://ncbi.nlm.nih.gov/pubmed/24248342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302840110
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