Influence of Activin A Supplementation During Human Embryonic Stem Cell Derivation on Germ Cell Differentiation Potential

Human embryonic stem cells (hESCs) are more similar to “primed” mouse epiblast stem cells (mEpiSCs). mEpiSCs, which are derived in Activin A, show an increased propensity to form primordial germ cell (PGC)-like cells in response to bone morphogenic protein 4 (BMP4). Hence, we hypothesized that hESCs...

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Autori principali: Duggal, Galbha, Heindryckx, Björn, Warrier, Sharat, O'Leary, Thomas, Van der Jeught, Margot, Lierman, Sylvie, Vossaert, Liesbeth, Deroo, Tom, Deforce, Dieter, Chuva de Sousa Lopes, Susana M., De Sutter, Petra
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2013
Soggetti:
Original Research Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856713/
https://ncbi.nlm.nih.gov/pubmed/23829223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2013.0024
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