Influence of Activin A Supplementation During Human Embryonic Stem Cell Derivation on Germ Cell Differentiation Potential

Human embryonic stem cells (hESCs) are more similar to “primed” mouse epiblast stem cells (mEpiSCs). mEpiSCs, which are derived in Activin A, show an increased propensity to form primordial germ cell (PGC)-like cells in response to bone morphogenic protein 4 (BMP4). Hence, we hypothesized that hESCs...

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Bibliographische Detailangaben
Hauptverfasser: Duggal, Galbha, Heindryckx, Björn, Warrier, Sharat, O'Leary, Thomas, Van der Jeught, Margot, Lierman, Sylvie, Vossaert, Liesbeth, Deroo, Tom, Deforce, Dieter, Chuva de Sousa Lopes, Susana M., De Sutter, Petra
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2013
Schlagworte:
Original Research Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856713/
https://ncbi.nlm.nih.gov/pubmed/23829223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2013.0024
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