Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

Targeted genome editing technologies have enabled a broad range of research and medical applications. The Cas9 nuclease from the microbial CRISPR-Cas system is targeted to specific genomic loci by a 20-nt guide sequence, which can tolerate certain mismatches to the DNA target and thereby promote und...

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Main Authors: Ran, F. Ann, Hsu, Patrick D., Lin, Chie-Yu, Gootenberg, Jonathan S., Konermann, Silvana, Trevino, Alexandro, Scott, David A., Inoue, Azusa, Matoba, Shogo, Zhang, Yi, Zhang, Feng
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856256/
https://ncbi.nlm.nih.gov/pubmed/23992846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.08.021
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