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RPA coordinates DNA end resection and prevents formation of DNA hairpins

Replication Protein A (RPA) is an essential eukaryotic single-stranded DNA binding protein with a central role in DNA metabolism. RPA directly participates in DNA double-strand break repair by stimulating 5’-3’ end resection by the Sgs1/BLM helicase and Dna2 endonuclease in vitro. Here we investigat...

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Bibliografske podrobnosti
Main Authors: Chen, Huan, Lisby, Michael, Symington, Lorraine S
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855855/
https://ncbi.nlm.nih.gov/pubmed/23706822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.04.032
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