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Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2
In this study, we investigate the interplay between Ku, a central non-homologous end-joining component, and the Mre11–Rad50–Xrs2 (MRX) complex and Sae2, end-processing factors crucial for initiating 5′-3′ resection of double-strand break (DSB) ends. We show that in the absence of end protection by K...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2957202/ https://ncbi.nlm.nih.gov/pubmed/20729809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.193 |
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