Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection

Homologous recombination requires nucleolytic degradation (resection) of DNA double-strand break (DSB) ends. In Saccharomyces cerevisiae, the MRX complex and Sae2 are involved in the onset of DSB resection, whereas extensive resection requires Exo1 and the concerted action of Dna2 and Sgs1. Here, we...

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Bibliografiske detaljer
Udgivet i:EMBO Rep
Main Authors: Bonetti, Diego, Villa, Matteo, Gobbini, Elisa, Cassani, Corinne, Tedeschi, Giulia, Longhese, Maria Pia
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2015
Fag:
Scientific Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364874/
https://ncbi.nlm.nih.gov/pubmed/25637499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439764
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