Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners

The Mre11-Rad50-Xrs2 (MRX) complex detects and processes DNA double-strand breaks (DSBs). Its DNA binding and processing activities are regulated by transitions between an ATP-bound state and a post-hydrolysis cutting state that is nucleolytically active. Mre11 endonuclease activity is stimulated by...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Marsella, Antonio, Gobbini, Elisa, Cassani, Corinne, Tisi, Renata, Cannavo, Elda, Reginato, Giordano, Cejka, Petr, Longhese, Maria Pia
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8028314/
https://ncbi.nlm.nih.gov/pubmed/33789097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108906
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