Physiological protein blocks direct the Mre11–Rad50–Xrs2 and Sae2 nuclease complex to initiate DNA end resection

DNA double-strand break repair by homologous recombination is initiated by DNA end resection, which is commenced by the Mre11–Rad50–Xrs2 complex and Sae2 in yeast. Here we report that the nonhomologous end joining factor Ku limits the exonuclease activity of Mre11 and promotes its endonuclease to cl...

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Bibliografische gegevens
Gepubliceerd in:Genes Dev
Hoofdauteurs: Reginato, Giordano, Cannavo, Elda, Cejka, Petr
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2017
Onderwerpen:
Research Communication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5795779/
https://ncbi.nlm.nih.gov/pubmed/29321179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.308254.117
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