Plasticity of the Mre11–Rad50–Xrs2–Sae2 nuclease ensemble in the processing of DNA-bound obstacles

The budding yeast Mre11–Rad50–Xrs2 (MRX) complex and Sae2 function together in DNA end resection during homologous recombination. Here we show that the Ku complex shields DNA ends from exonucleolytic digestion but facilitates endonucleolytic scission by MRX with a dependence on ATP and Sae2. The inc...

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Bibliografiska uppgifter
I publikationen:Genes Dev
Huvudupphovsmän: Wang, Weibin, Daley, James M., Kwon, Youngho, Krasner, Danielle S., Sung, Patrick
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2017
Ämnen:
Research Communication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5795780/
https://ncbi.nlm.nih.gov/pubmed/29321177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.307900.117
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