Plasticity of the Mre11–Rad50–Xrs2–Sae2 nuclease ensemble in the processing of DNA-bound obstacles

The budding yeast Mre11–Rad50–Xrs2 (MRX) complex and Sae2 function together in DNA end resection during homologous recombination. Here we show that the Ku complex shields DNA ends from exonucleolytic digestion but facilitates endonucleolytic scission by MRX with a dependence on ATP and Sae2. The inc...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Wang, Weibin, Daley, James M., Kwon, Youngho, Krasner, Danielle S., Sung, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2017
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5795780/
https://ncbi.nlm.nih.gov/pubmed/29321177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.307900.117
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