Sae2 promotes DNA damage resistance by removing the Mre11–Rad50–Xrs2 complex from DNA and attenuating Rad53 signaling

The Mre11–Rad50–Xrs2/NBS1 (MRX/N) nuclease/ATPase complex plays structural and catalytic roles in the repair of DNA double-strand breaks (DSBs) and is the DNA damage sensor for Tel1/ATM kinase activation. Saccharomyces cerevisiae Sae2 can function with MRX to initiate 5′-3′ end resection and also pl...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Chen, Huan, Donnianni, Roberto A., Handa, Naofumi, Deng, Sarah K., Oh, Julyun, Timashev, Leonid A., Kowalczykowski, Stephen C., Symington, Lorraine S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403154/
https://ncbi.nlm.nih.gov/pubmed/25831494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503331112
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