Xrs2 dependent and independent functions of the Mre11-Rad50 complex

The Mre11-Rad50-Xrs2/Nbs1 (MRX/N) complex orchestrates the cellular response to DSBs through its structural, enzymatic and signaling roles. Xrs2/Nbs1 is essential for nuclear translocation of Mre11, but its role as a component of the complex is not well defined. Here we demonstrate that nuclear loca...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Oh, Julyun, Al-Zain, Amr, Cannavo, Elda, Cejka, Petr, Symington, Lorraine S.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123801/
https://ncbi.nlm.nih.gov/pubmed/27746018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.09.011
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