Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance

Sae2 cooperates with the Mre11–Rad50-Xrs2 (MRX) complex to initiate resection of DNA double-strand breaks (DSBs) and to maintain the DSB ends in close proximity to allow their repair. How these diverse MRX-Sae2 functions contribute to DNA damage resistance is not known. Here, we describe mre11 allel...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Cassani, Corinne, Gobbini, Elisa, Vertemara, Jacopo, Wang, Weibin, Marsella, Antonio, Sung, Patrick, Tisi, Renata, Zampella, Giuseppe, Longhese, Maria Pia
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888019/
https://ncbi.nlm.nih.gov/pubmed/29420790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky086
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