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Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance
Sae2 cooperates with the Mre11–Rad50-Xrs2 (MRX) complex to initiate resection of DNA double-strand breaks (DSBs) and to maintain the DSB ends in close proximity to allow their repair. How these diverse MRX-Sae2 functions contribute to DNA damage resistance is not known. Here, we describe mre11 allel...
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| Publié dans: | Nucleic Acids Res |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5888019/ https://ncbi.nlm.nih.gov/pubmed/29420790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky086 |
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