Tenofovir and tenofovir disoproxil fumarate pharmacokinetics from intravaginal rings

OBJECTIVES: To compare the distribution of tenofovir in sheep vaginal lumen, tissue, and plasma following topical delivery of the antiretroviral drug from intravaginal rings, either as tenofovir or the disoproxil fumarate prodrug. DESIGN: Comparative pharmacokinetic study in sheep. METHOD: Intravagi...

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Autores principales: Moss, John A., Baum, Marc M., Malone, Amanda M., Kennedy, Sean, Kopin, Etana, Nguyen, Cali, Gilman, Josh, Butkyavichene, Irina, Willis, Robyn A., Vincent, Kathleen L., Motamedi, Massoud, Smith, Thomas J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855348/
https://ncbi.nlm.nih.gov/pubmed/22210639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3283509abb
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