Tenofovir and tenofovir disoproxil fumarate pharmacokinetics from intravaginal rings

OBJECTIVES: To compare the distribution of tenofovir in sheep vaginal lumen, tissue, and plasma following topical delivery of the antiretroviral drug from intravaginal rings, either as tenofovir or the disoproxil fumarate prodrug. DESIGN: Comparative pharmacokinetic study in sheep. METHOD: Intravagi...

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Détails bibliographiques
Auteurs principaux: Moss, John A., Baum, Marc M., Malone, Amanda M., Kennedy, Sean, Kopin, Etana, Nguyen, Cali, Gilman, Josh, Butkyavichene, Irina, Willis, Robyn A., Vincent, Kathleen L., Motamedi, Massoud, Smith, Thomas J.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855348/
https://ncbi.nlm.nih.gov/pubmed/22210639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3283509abb
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