Identifying the translational gap in the evaluation of drug-induced QT(c) interval prolongation

AIMS: Given the similarities in QT(c) response between dogs and humans, dogs are used in pre-clinical cardiovascular safety studies. The objective of our investigation was to characterize the PKPD relationships and identify translational gaps across species following the administration of three comp...

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Autori principali: Chain, Anne SY, Dubois, Vincent FS, Danhof, Meindert, Sturkenboom, Miriam CJM, Della Pasqua, Oscar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2013
Soggetti:
Translational Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853530/
https://ncbi.nlm.nih.gov/pubmed/23351036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12082
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