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The role of concentration−effect relationships in the assessment of QT(c) interval prolongation
Population pharmacokinetic and pharmacokinetic−pharmacodynamic (PKPD) modelling has been widely used in clinical research. Yet, its application in the evaluation of cardiovascular safety remains limited, particularly in the evaluation of pro-arrhythmic effects. Here we discuss the advantages of disa...
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| 出版年: | Br J Clin Pharmacol |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Blackwell Science Inc
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4294082/ https://ncbi.nlm.nih.gov/pubmed/24938719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12443 |
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