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Translating QT interval prolongation from conscious dogs to humans
AIM: In spite of screening procedures in early drug development, uncertainty remains about the propensity of new chemical entities (NCEs) to prolong the QT/QTc interval. The evaluation of proarrhythmic activity using a comprehensive in vitro proarrhythmia assay does not fully account for pharmacokin...
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| Pubblicato in: | Br J Clin Pharmacol |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5237692/ https://ncbi.nlm.nih.gov/pubmed/27614058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13123 |
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