Translating QT interval prolongation from conscious dogs to humans

AIM: In spite of screening procedures in early drug development, uncertainty remains about the propensity of new chemical entities (NCEs) to prolong the QT/QTc interval. The evaluation of proarrhythmic activity using a comprehensive in vitro proarrhythmia assay does not fully account for pharmacokin...

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Bibliographic Details
Published in:Br J Clin Pharmacol
Main Authors: Dubois, Vincent F. S., Smania, Giovanni, Yu, Huixin, Graf, Ramona, Chain, Anne S. Y., Danhof, Meindert, Della Pasqua, Oscar
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Translational Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5237692/
https://ncbi.nlm.nih.gov/pubmed/27614058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13123
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