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Model-based evaluation of drug-induced QTc prolongation for compounds in early development
AIMS: Significant differences between dogs and humans have been observed in the concentration–QTc effect relationship of compounds with known pro-arrhythmic properties. These findings suggest that interspecies differences must be considered when evaluating drug effects. The aim of this study was to...
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| Publicado no: | Br J Clin Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4294084/ https://ncbi.nlm.nih.gov/pubmed/25099645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12482 |
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