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Pharmacokinetic–pharmacodynamic modelling of drug‐induced QTc interval prolongation in man: prediction from in vitro human ether‐à‐go‐go‐related gene binding and functional inhibition assays and conscious dog studies
BACKGROUND AND PURPOSE: Functional measures of human ether‐à‐go‐go‐related gene (hERG; K(v)11.1) channel inhibition have been prioritized as an in vitro screening tool for candidate molecules. However, it is unclear how these results can be translated to humans. Here, we explore how data on drug bin...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5055135/ https://ncbi.nlm.nih.gov/pubmed/27427789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13558 |
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