Načítá se...

Characterizing QT interval prolongation in early clinical development: a case study with methadone

Recently, we have shown how pharmacokinetic–pharmacodynamic (PKPD) modeling can be used to assess the probability of QT interval prolongation both in dogs and humans. A correlation between species has been identified for a drug‐specific parameter, making it possible to prospectively evaluate nonclin...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Pharmacol Res Perspect
Hlavní autoři: Dubois, Vincent F. S., Danhof, Meindert, Della Pasqua, Oscar
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461648/
https://ncbi.nlm.nih.gov/pubmed/28596836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.284
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!