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Characterizing QT interval prolongation in early clinical development: a case study with methadone
Recently, we have shown how pharmacokinetic–pharmacodynamic (PKPD) modeling can be used to assess the probability of QT interval prolongation both in dogs and humans. A correlation between species has been identified for a drug‐specific parameter, making it possible to prospectively evaluate nonclin...
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| Publicado no: | Pharmacol Res Perspect |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5461648/ https://ncbi.nlm.nih.gov/pubmed/28596836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.284 |
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