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The role of concentration−effect relationships in the assessment of QT(c) interval prolongation
Population pharmacokinetic and pharmacokinetic−pharmacodynamic (PKPD) modelling has been widely used in clinical research. Yet, its application in the evaluation of cardiovascular safety remains limited, particularly in the evaluation of pro-arrhythmic effects. Here we discuss the advantages of disa...
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| Pubblicato in: | Br J Clin Pharmacol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Blackwell Science Inc
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4294082/ https://ncbi.nlm.nih.gov/pubmed/24938719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12443 |
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