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Identifying the translational gap in the evaluation of drug-induced QT(c) interval prolongation
AIMS: Given the similarities in QT(c) response between dogs and humans, dogs are used in pre-clinical cardiovascular safety studies. The objective of our investigation was to characterize the PKPD relationships and identify translational gaps across species following the administration of three comp...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Blackwell Science Inc
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3853530/ https://ncbi.nlm.nih.gov/pubmed/23351036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12082 |
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