Axonal Stress Kinase Activation and Tau Misbehavior Induced by Kinesin-1 Transport Defects

Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the microtubule binding protein tau. While mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP17) causes aberrant microtubule binding...

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Bibliographic Details
Main Authors: Falzone, Tomás L., Stokin, Gorazd B., Lillo, Concepción, Rodrigues, Elizabeth M., Westerman, Eileen L., Williams, David S., Goldstein, Lawrence S. B.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849468/
https://ncbi.nlm.nih.gov/pubmed/19420244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0780-09.2009
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