Tau Isoforms Imbalance Impairs the Axonal Transport of the Amyloid Precursor Protein in Human Neurons

Tau, as a microtubule (MT)-associated protein, participates in key neuronal functions such as the regulation of MT dynamics, axonal transport, and neurite outgrowth. Alternative splicing of exon 10 in the tau primary transcript gives rise to protein isoforms with three (3R) or four (4R) MT binding r...

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Publicat a:J Neurosci
Autors principals: Lacovich, Valentina, Espindola, Sonia L., Alloatti, Matías, Pozo Devoto, Victorio, Cromberg, Lucas E., Čarná, Mária E., Forte, Giancarlo, Gallo, Jean-Marc, Bruno, Luciana, Stokin, Gorazd B., Avale, M. Elena, Falzone, Tomás L.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705673/
https://ncbi.nlm.nih.gov/pubmed/28053030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2305-16.2016
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