Tau Isoforms Imbalance Impairs the Axonal Transport of the Amyloid Precursor Protein in Human Neurons

Tau, as a microtubule (MT)-associated protein, participates in key neuronal functions such as the regulation of MT dynamics, axonal transport, and neurite outgrowth. Alternative splicing of exon 10 in the tau primary transcript gives rise to protein isoforms with three (3R) or four (4R) MT binding r...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Lacovich, Valentina, Espindola, Sonia L., Alloatti, Matías, Pozo Devoto, Victorio, Cromberg, Lucas E., Čarná, Mária E., Forte, Giancarlo, Gallo, Jean-Marc, Bruno, Luciana, Stokin, Gorazd B., Avale, M. Elena, Falzone, Tomás L.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2017
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705673/
https://ncbi.nlm.nih.gov/pubmed/28053030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2305-16.2016
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