Tau Isoforms Imbalance Impairs the Axonal Transport of the Amyloid Precursor Protein in Human Neurons

Tau, as a microtubule (MT)-associated protein, participates in key neuronal functions such as the regulation of MT dynamics, axonal transport, and neurite outgrowth. Alternative splicing of exon 10 in the tau primary transcript gives rise to protein isoforms with three (3R) or four (4R) MT binding r...

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Vydáno v:J Neurosci
Hlavní autoři: Lacovich, Valentina, Espindola, Sonia L., Alloatti, Matías, Pozo Devoto, Victorio, Cromberg, Lucas E., Čarná, Mária E., Forte, Giancarlo, Gallo, Jean-Marc, Bruno, Luciana, Stokin, Gorazd B., Avale, M. Elena, Falzone, Tomás L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2017
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705673/
https://ncbi.nlm.nih.gov/pubmed/28053030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2305-16.2016
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