αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease

The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role. However, the mechanisms by which αSyn and its disease-associated allelic variants cause mitochondrial dysfunction remain unknown. Here, we...

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Publicado no:Sci Rep
Main Authors: Pozo Devoto, Victorio Martin, Dimopoulos, Nicolas, Alloatti, Matías, Pardi, María Belén, Saez, Trinidad M., Otero, María Gabriela, Cromberg, Lucas Eneas, Marín-Burgin, Antonia, Scassa, Maria Elida, Stokin, Gorazd B., Schinder, Alejandro F., Sevlever, Gustavo, Falzone, Tomás Luis
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5506004/
https://ncbi.nlm.nih.gov/pubmed/28698628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05334-9
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