Axonal Stress Kinase Activation and Tau Misbehavior Induced by Kinesin-1 Transport Defects

Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the microtubule binding protein tau. While mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP17) causes aberrant microtubule binding...

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Detalhes bibliográficos
Main Authors: Falzone, Tomás L., Stokin, Gorazd B., Lillo, Concepción, Rodrigues, Elizabeth M., Westerman, Eileen L., Williams, David S., Goldstein, Lawrence S. B.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849468/
https://ncbi.nlm.nih.gov/pubmed/19420244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0780-09.2009
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