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The mitochondrial anti-viral protein MAVS associates with NLRP3 and regulates its inflammasome activity()
NLRP3 assembles an inflammasome complex that activates caspase-1 upon sensing various danger signals derived from pathogenic infection, tissue damage and environmental toxins. How NLRP3 senses these various stimuli is still poorly understood, but mitochondria and mitochondrial reactive oxygen specie...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3848201/ https://ncbi.nlm.nih.gov/pubmed/24048902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301170 |
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