Ribotoxic Stress through p38 Mitogen-activated Protein Kinase Activates in Vitro the Human Pyrin Inflammasome

Human pyrin with gain-of-function mutations in its B30.2/SPRY domain causes the autoinflammatory disease familial Mediterranean fever by assembling an ASC-dependent inflammasome that activates caspase-1. Wild-type human pyrin can also form an inflammasome complex with ASC after engagement by autoinf...

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Detalhes bibliográficos
Main Authors: Yu, Je-Wook, Farias, Andrew, Hwang, Inhwa, Fernandes-Alnemri, Teresa, Alnemri, Emad S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630843/
https://ncbi.nlm.nih.gov/pubmed/23479736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.448795
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