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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
Host- and pathogen-associated cytoplasmic double-stranded DNA triggers the activation of a NALP3 (also known as cryopyrin and NLRP3)-independent inflammasome 1, which activates caspase-1 leading to maturation of pro-interleukin-1β and inflammation. The nature of the cytoplasmic-DNA-sensing inflammas...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862225/ https://ncbi.nlm.nih.gov/pubmed/19158676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07710 |
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