Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants

The molecular mechanism by which mutations in the cytoskeleton-organizing protein PSTPIP1 cause the autoinflammatory PAPA syndrome is still elusive. Here, we demonstrate that PSTPIP1 requires the Familial Mediterranean Fever protein pyrin to assemble the ASC pyroptosome, a molecular platform that re...

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Autores principales: Yu, Je-Wook, Fernandes-Alnemri, Teresa, Datta, Pinaki, Wu, Jianghong, Juliana, Christine, Solorzano, Leobaldo, McCormick, Margaret, Zhang, ZhiJia, Alnemri, Emad S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719761/
https://ncbi.nlm.nih.gov/pubmed/17964261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.08.029
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