Discovery of VU0409106: A negative allosteric modulator of mGlu(5) with activity in a mouse model of anxiety

Development of SAR in an aryl ether series of mGlu(5) NAMs leading to the identification of tool compound VU0409106 is described in this Letter. VU0409106 is a potent and selective negative allosteric modulator of mGlu(5) that binds at the known allosteric binding site and demonstrates good CNS expo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Manka, Jason T., Bates, Brittney S., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846293/
https://ncbi.nlm.nih.gov/pubmed/24074843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.09.001
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