Chemistry, Pharmacology, and Behavioral Studies Identify Chiral Cyclopropanes as Selective α4β2- Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile. Part II

A 3-pyridyl ether scaffold bearing a cyclopropane-containing side chain was recently identified in our efforts to create novel antidepressants that act as partial agonists at α4β2-nicotinic acetylcholine receptors. In this study, a systematic structure-activity relationship investigation was carried...

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Hlavní autoři: Zhang, Han-Kun, Yu, Li-Fang, Eaton, J. Brek, Whiteaker, Paul, Onajole, Oluseye K., Hanania, Taleen, Brunner, Daniela, Lukas, Ronald J., Kozikowski, Alan P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843973/
https://ncbi.nlm.nih.gov/pubmed/23734673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400510u
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