Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor.

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired defect of bone marrow stem cells in which the affected clones produce erythrocytes (also granulocytes and platelets) with membranes that are abnormally sensitive to complement-mediated lysis. Abnormal erythrocytes (E) from patients with PNH (P...

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Autores principales: Nicholson-Weller, A, March, J P, Rosenfeld, S I, Austen, K F
Formato: Artigo
Lenguaje:Inglês
Publicado: 1983
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC384189/
https://ncbi.nlm.nih.gov/pubmed/6576376
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