Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor.

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired defect of bone marrow stem cells in which the affected clones produce erythrocytes (also granulocytes and platelets) with membranes that are abnormally sensitive to complement-mediated lysis. Abnormal erythrocytes (E) from patients with PNH (P...

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Détails bibliographiques
Auteurs principaux: Nicholson-Weller, A, March, J P, Rosenfeld, S I, Austen, K F
Format: Artigo
Langue:Inglês
Publié: 1983
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC384189/
https://ncbi.nlm.nih.gov/pubmed/6576376
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