Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor.

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired defect of bone marrow stem cells in which the affected clones produce erythrocytes (also granulocytes and platelets) with membranes that are abnormally sensitive to complement-mediated lysis. Abnormal erythrocytes (E) from patients with PNH (P...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Nicholson-Weller, A, March, J P, Rosenfeld, S I, Austen, K F
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1983
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6576376/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.16.5066
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