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Unfolding of a Small Protein Proceeds via Dry and Wet Globules and a Solvated Transition State

Dissecting a protein unfolding process into individual steps can provide valuable information on the forces that maintain the integrity of the folded structure. Solvation of the protein core determines stability, but it is not clear when such solvation occurs during unfolding. In this study, far-UV...

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Detalhes bibliográficos
Main Authors: Sarkar, Saswata Sankar, Udgaonkar, Jayant B., Krishnamoorthy, Guruswamy
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838737/
https://ncbi.nlm.nih.gov/pubmed/24268151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.09.048
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