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Direct evidence for a dry molten globule intermediate during the unfolding of a small protein

Little is known about how proteins begin to unfold. In particular, how and when water molecules penetrate into the protein interior during unfolding, thereby enabling the dissolution of specific structure, is poorly understood. The hypothesis that the native state expands initially into a dry molten...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jha, Santosh Kumar, Udgaonkar, Jayant B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718347/
https://ncbi.nlm.nih.gov/pubmed/19617531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905744106
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