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Direct evidence for a dry molten globule intermediate during the unfolding of a small protein

Little is known about how proteins begin to unfold. In particular, how and when water molecules penetrate into the protein interior during unfolding, thereby enabling the dissolution of specific structure, is poorly understood. The hypothesis that the native state expands initially into a dry molten...

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Autori principali: Jha, Santosh Kumar, Udgaonkar, Jayant B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718347/
https://ncbi.nlm.nih.gov/pubmed/19617531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0905744106
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