Mast cells suppress murine GVHD in a mechanism independent of CD4(+)CD25(+) regulatory T cells

To investigate the role of mast cells in hematopoietic cell transplantation, we assessed graft-versus-host disease (GVHD) in C57BL/6-Kit(W-sh/W-sh) recipients, which virtually lack mast cells, compared with C57BL/6 WT recipients. GVHD was severely exacerbated in C57BL/6-Kit(W-sh/W-sh) mice (median s...

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Main Authors: Leveson-Gower, Dennis B., Sega, Emanuela I., Kalesnikoff, Janet, Florek, Mareike, Pan, Yuqiong, Pierini, Antonio, Galli, Stephen J., Negrin, Robert S.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2013
主題:
Transplantation
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837515/
https://ncbi.nlm.nih.gov/pubmed/24030387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-08-519157
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