Freeze and Thaw of CD4(+)CD25(+)Foxp3(+) Regulatory T Cells Results in Loss of CD62L Expression and a Reduced Capacity to Protect against Graft-versus-Host Disease

The adoptive transfer of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) in murine models of allogeneic hematopoietic cell transplantation (HCT) has been shown to protect recipient mice from lethal acute graft-versus-host disease (GVHD) and this approach is being actively investigated in human clin...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Florek, Mareike, Schneidawind, Dominik, Pierini, Antonio, Baker, Jeanette, Armstrong, Randall, Pan, Yuqiong, Leveson-Gower, Dennis, Negrin, Robert, Meyer, Everett
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691201/
https://ncbi.nlm.nih.gov/pubmed/26693907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145763
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